Structure of PDB 7pxc Chain 2 Binding Site BS01

Receptor Information
>7pxc Chain 2 (length=215) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSLQKISELY
DRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTL
GTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADEPHFVVMG
GTTEPIANALKESYAENASLTDALRIAVAALRALGVASLEVAVLDANRPR
RAFRRITGSALQALL
Ligand information
>7pxc Chain 1 (length=5) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LGQYL
Receptor-Ligand Complex Structure
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PDB7pxc Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Resolution3.84 Å
Binding residue
(original residue number in PDB)		G23 R26 A27 K28 L50 K52 G66 K67 F68 F71 E119
Binding residue
(residue number reindexed from 1)		G16 R19 A20 K21 L43 K45 G59 K60 F61 F64 E112
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0019941 modification-dependent protein catabolic process
GO:0030682 symbiont-mediated perturbation of host defenses
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0019773 proteasome core complex, alpha-subunit complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pxc, PDBe:7pxc, PDBj:7pxc
PDBsum7pxc
PubMed35022401
UniProtP9WHU1|PSA_MYCTU Proteasome subunit alpha (Gene Name=prcA)

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