Structure of PDB 7pmk Chain 2 Binding Site BS01

Receptor Information
>7pmk Chain 2 (length=655) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIDPLREELTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDET
GRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFD
LVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTG
VVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGP
FRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGE
EVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRVFSWTEEEEREFRK
ISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGD
INVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPIT
KEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGI
VTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDL
VDEEADERLATFVVDSHVRSHPENLNARQRRLQRQRKKEEEISPIPQELL
MKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESI
LRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAI
YTLGH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pmk A conserved mechanism for regulating replisome disassembly in eukaryotes.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S572 V574 S579 V580 W589 K633 A634
Binding residue
(residue number reindexed from 1)		S386 V388 S393 V394 W403 K447 A448
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0006974 DNA damage response
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pmk, PDBe:7pmk, PDBj:7pmk
PDBsum7pmk
PubMed34700328
UniProtP29469|MCM2_YEAST DNA replication licensing factor MCM2 (Gene Name=MCM2)

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