Structure of PDB 7plo Chain 2 Binding Site BS01

Receptor Information
>7plo Chain 2 (length=697) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKER
ISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVL
AMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGV
LPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEET
IYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIY
HNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLS
KDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDIN
VLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSRE
WTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVT
SLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVD
PVQDEMLARFVVGSHVRHHPSTYGVEPLPQEVLKKYIIYAKERVHPKLNQ
MDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVI
EDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILK
QLVAEQVTYQRNVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S552 V554 V560 W569 K613 A614
Binding residue
(residue number reindexed from 1)		S384 V386 V392 W401 K445 A446
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
GO:0042393 histone binding
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006334 nucleosome assembly
GO:0006915 apoptotic process
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0071353 cellular response to interleukin-4
GO:0090102 cochlea development
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtP49736|MCM2_HUMAN DNA replication licensing factor MCM2 (Gene Name=MCM2)

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