Structure of PDB 7nvw Chain 2 Binding Site BS01

Receptor Information

>7nvw Chain 2 (length=390) Species: 9606 (Homo sapiens)

NLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLP
QAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLILNPIFRQNLRIALLG
GVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEP
PCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFS
DSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINQPGFIVVETNYRLYAY
TESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFL
RTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDF
ELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQ

Ligand information

>7nvw Chain W (length=15) Species: 9606 (Homo sapiens)

AKERPIWLRESTVQG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7nvw Structures of mammalian RNA polymerase II pre-initiation complexes.
• Resolution: 4.3 Å
• Binding residue (original residue number in PDB): D389 L396
• Binding residue (residue number reindexed from 1): D321 L328

Gene Ontology

Molecular Function

• GO:0001671 ATPase activator activity
• GO:0003690 double-stranded DNA binding
• GO:0005515 protein binding
• GO:0016251 RNA polymerase II general transcription initiation factor activity

Biological Process

• GO:0006281 DNA repair
• GO:0006289 nucleotide-excision repair
• GO:0006366 transcription by RNA polymerase II

Cellular Component

• GO:0000438 core TFIIH complex portion of holo TFIIH complex
• GO:0000439 transcription factor TFIIH core complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005669 transcription factor TFIID complex
• GO:0005675 transcription factor TFIIH holo complex
• GO:0016607 nuclear speck

External links

• PDB: RCSB:7nvw, PDBe:7nvw, PDBj:7nvw
• PDBsum: 7nvw
• PubMed: 33902107
• UniProt: Q92759|TF2H4_HUMAN General transcription factor IIH subunit 4 (Gene Name=GTF2H4)