Structure of PDB 7a0r Chain 2 Binding Site BS01

Receptor Information

>7a0r Chain 2 (length=47) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

MKRTYQPNNRKRAKTHGFRARMKTKSGRNILARRRAKGRHQLTVSDE

Ligand information

>7a0r Chain X (length=2730)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaac
cgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcugg
aaagcuacaccucagaaggugagaguccuguaggcgaacgagccugagua
ggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaag
gcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggug
aaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuac
aagcagucauggcaccuuaugcguguuauggcgugccuauugaagcauga
gccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcgg
agcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucg
aaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggc
ggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuua
ggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaaugu
auugagguacagccucggauguugaccauguccuguagagcacucacaag
gcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggaguga
ggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccauc
agcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcau
agacagccaggagguuggcuuagaagcagccacccuucaaagagugcgua
auagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagu
gaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggg
gagcguucaguccgcggagaagccauaccggaaggagugguggagccgac
ugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucu
ucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaag
ucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaa
gauuccugcaccgaucauguggagugauggagggacgcauuacgcuaucc
aaugccaagcuauggcuaugcugguugguacgcucaagggcgaucggguc
agaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaa
gcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaac
augauugcccguaccgcaaaccgacacagguguccgagugucaaugcacu
aaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccgua
acuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggc
ccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacagugg
acguauagggugugacgccugcccggugccggaaggucaaguggagcggu
gcaagcugcgaaaugaagccccggugaacggcggcuaagguagcgaaauu
ccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgc
ugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggcc
uacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggca
uugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuu
ucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaa
auguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucug
uagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagc
agggaggaaacucgggcuuagugaaccggugguaccguguggaagggcca
ucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccg
agaguccauaucggcggggagguuuggcaccucgaugucggcucgucgca
uccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagc
ggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccg
cuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccg
gagugaacggaccgcuggucucccugcugucguaccaacggcacaugcag
gguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagc
cagccccaagaugaguucucccacuguuuaucagguaagacucccggaag
accaccggguuaagaggccaggcgugcacgcauagcaauguguucagcgg
acuggugcucaucagucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<....<
<<<<.<<....>>.>>>>>......<<<....<<..<<<...<<<<<...
...>>>>>((......<<<.....))>>>...>>>....>>.>>>.....
<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>
>>......>>.>>>>>>.>>..............<<....>>....>>..
.......<<<<....>>>>..................>>>>>>>>>>>..
.....<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.
<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>..
.<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>.
.....>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<
<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..
<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.
<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<...
...<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<...
...>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>
>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>
>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>
>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>
><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....(
(<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<....
....>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<
<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...
<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>
>>....>>>>>...>>>...>>>>.........>>>>...>>......>>
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>
..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...
.<<..>>.....>>>>><<<<<<<<...>>>>>>>>............<<
<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.
......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<
....>>>>>...>>...>>>>>>>>..>>>>>..........<.......
....<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..
>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>
..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<
<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<.......>.
>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....
.......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.
....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>
>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>
>>>.............>>>>..>>>>>>.......<<<<...<<<<<<..
.<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<.
.<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>
>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>
>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>
>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>
>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>
>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<...
....>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>.
.>>>>>.>>>...>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a0r Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): M1 K2 R3 T4 Y5 Q6 P7 N8 N9 R10 K11 R12 A13 K14 H16 G17 F18 R19 R21 M22 S26 I30 R33 R35 K37 G38 R39 H40 L42 S45 D46
• Binding residue (residue number reindexed from 1): M1 K2 R3 T4 Y5 Q6 P7 N8 N9 R10 K11 R12 A13 K14 H16 G17 F18 R19 R21 M22 S26 I30 R33 R35 K37 G38 R39 H40 L42 S45 D46

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7a0r, PDBe:7a0r, PDBj:7a0r
• PDBsum: 7a0r
• PubMed: 34417608
• UniProt: Q9RSH2|RL34_DEIRA Large ribosomal subunit protein bL34 (Gene Name=rpmH)