Structure of PDB 6rax Chain 2 Binding Site BS01

Receptor Information
>6rax Chain 2 (length=605) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLA
NKEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISEL
PLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGP
FVQSQNTEIKPGSCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAG
RIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVFATV
IIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGH
DYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEK
VAPRAVFTTGQGASAVGLYVRRNPVSREWTLEAGALVLADQGVCLIDEFD
KMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPS
MTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHEIP
QDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRH
IESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVMKKMRS
TFQKY
Ligand information
Receptor-Ligand Complex Structure
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PDB6rax Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Resolution3.99 Å
Binding residue
(original residue number in PDB)		S537 Y544 R546 K598 A599
Binding residue
(residue number reindexed from 1)		S364 Y369 R371 K423 A424
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0030261 chromosome condensation
GO:0032508 DNA duplex unwinding
GO:0051301 cell division
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rax, PDBe:6rax, PDBj:6rax
PDBsum6rax
PubMed31484077
UniProtP49735|MCM2_DROME DNA replication licensing factor Mcm2 (Gene Name=Mcm2)

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