Structure of PDB 5xjl Chain 2 Binding Site BS01

Receptor Information
>5xjl Chain 2 (length=204) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EELMPRLLPVTPQEYLRRVQIEAAQCPDVVVAQIDPKQSVNISLSGCQPA
PEGYSPTLQWQQQQVAQFSTVRQNVNKHRSHWMPKSEDEEGWKKFCLGEI
GFPPLLSIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEK
PLLPEAHSLIRQLARRCSEVRLLVDSKDDERVPALNLLICLVSRYFDQRD
LADE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xjl Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly
Resolution2.5 Å
Binding residue
(original residue number in PDB)		W102 Q105 Q106 Q109 P178 L179 L180 S181 G212 R213 Y216 P257 N260
Binding residue
(residue number reindexed from 1)		W60 Q63 Q64 Q67 P104 L105 L106 S107 G138 R139 Y142 P183 N186
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000387 spliceosomal snRNP assembly
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1905215 negative regulation of RNA binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016604 nuclear body
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex
GO:0097504 Gemini of coiled bodies

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xjl, PDBe:5xjl, PDBj:5xjl
PDBsum5xjl
PubMed21816274
UniProtO14893|GEMI2_HUMAN Gem-associated protein 2 (Gene Name=GEMIN2)

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