Structure of PDB 4wf9 Chain 2 Binding Site BS01

Receptor Information

>4wf9 Chain 2 (length=44) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325)

VKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA

Ligand information

>4wf9 Chain X (length=2712)

uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauauguauacauagcauaucagaaggcacacccggagaacugaaacauc
uuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcga
gcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguagg
acacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagau
gaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugag
uggauccugaguacgacggagcacgugaaauuccgucggaaucugggagg
accaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguac
cgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccug
aaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugc
cuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcagu
aaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuug
gucguagacccgaaaccaggugaucuacccuuggucagguugaaguucag
gcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacu
gaggguagcggagaaauuccaaucgaaccuggagauagcugguucucucc
gaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcac
uguuuggacgaggggguuaccgaauucagacaaacuccgaaugccaauua
auuuaacuugggagucagaacaugggugauaagguccguguucgaaaggg
aaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaa
aggauguggcguugcccagacaacuagcucacuagucgagugacacugcg
ccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuu
ggacaaugguaggagagcguucuaagggcguugaagcaugaucguaagga
cauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgg
gugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguc
cgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgaug
gauaacagguugauauuccuguaccaccuauaaucguaucgaugggggga
cgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguag
gcugaguauauccgguacucguggcugagcugugauggggagaagaaguc
guugauuucacacugccgagaaaagccucuagauagaauaggugcccgua
ccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcg
aacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaagg
ggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaag
cgacuguuuaucaaaaacacaggucucugcuaaaccgaaggugauguaua
ggggcugacgccugcccgugcuggaagguuaagaggagugguuagcugcg
aagcuacgaaucgaagccccaguaaacggcggccccuaagguagcgaaau
uccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggca
cugucucaacgagagacucggugaaaucauaguaccugugaagaugcagg
uuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugau
auugaaauucggcuuucuaacccgcaccacuuaucguggugggagacagu
gucaagcgggcaguuugacuggggcggucgccuccuaaaagguaacggag
gcgcucaaagguucccucagaaugguugaaaucauucauagaguguaaag
gcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaaga
cggacuuagugauccggugguuccgcauggaagggccaucgcucaacgga
uaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacauc
gacggggagguuuggcaccucgaugucggcucaucgcauccuggggcugu
agucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcu
ggguucagaacgucgugagacaguucggucccuauccgucgugggcguag
gaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauac
cucugguguaccaguugucgugccaacggcauagcuggguagcuaugugu
ggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaug
agauuucccaacuugguuauaagaucccucaaagaugaugagguuaauag
guucgagguggaagcauggugacauguggagcugacgaauacuaaucgau
cgaagacuuaau

<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>>.<<<<<<......>>>>>>..<<
<<<<<<<.......>>>>>>>.>>.>>....<<<<<......<<....>>
.......>>>>.>.........<<....>>..<<<<<......<<.....
>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<
<<<<<<...<..........<.<<<<<<<.<<<...<<<<<......>>>
>>((......<<<.....))>>>...>>>...>>>>>>>..>...>.>>>
>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<.
.<<<<>>>>>..)))......]].>>>>>>>.]]...............<
<....>>....]].........<<<<....>>>>................
..>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<
.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<..
...>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>
>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<
.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>
>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<
....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...
<<<<<<<....<<......>>....>>>>>>>..>>.>.....>>>>.>>
>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<
......>>>...<<<<.<<<...<<<(((.....<<<<<<..........
.<<..<<<<.<<<<........<<<<......>>>>....>>>>.>>>>.
>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..
>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.
>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<
<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>
>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>
>...<<<<<........>>>>>))<<<<<<<......<<<...<<<<...
.<<<<...<<...<......<<<...{.{...>>>...<....<<<<<.<
<<<<<..<.......>..>>>..>>>..>>>>>.....>...........
..>....>>...>>>>.........>>>.>.>>>...>>>>>>>>>>>..
>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<..
..<<<<<<<<.<<...............<<<<<.....<..>......>>
>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<
<<..<<<.........>>>..<<<<<<<.....<<<...>>>.......>
>>>>>>.<<<<<..<<.<<<<<<<..<<<...<<...<<<<<..<<.>>.
..>>>>>...>>...>>>>>>>>..>>>>..............<......
.....<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.
....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>
>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<
<<.<<<<.<..>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>
>>>>.>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>
>>..<<...<<<<<<<...<<<<<<......>>>>>>.....<<.[.(((
>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>
>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.........
....>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>
...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<..
....>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>
.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<
<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<
...<<<<...<<<<<<<<<<..}.}.>>>>>..>>>>>...>>>>.>>>>
>...<<<....<<<<<...........>>>>>....>>>.>>>>......
.>>>>>>>.<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<
<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>
>....>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4wf9 Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
• Resolution: 3.427 Å
• Binding residue (original residue number in PDB): V2 K3 R4 T5 Y6 Q7 P8 N9 K10 R11 K12 H13 K15 H17 F19 R20 K26 N27 R34 R35 R36 R37 G39 R40 K41
• Binding residue (residue number reindexed from 1): V1 K2 R3 T4 Y5 Q6 P7 N8 K9 R10 K11 H12 K14 H16 F18 R19 K25 N26 R33 R34 R35 R36 G38 R39 K40

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4wf9, PDBe:4wf9, PDBj:4wf9
• PDBsum: 4wf9
• PubMed: 26464510
• UniProt: Q2FUQ0|RL34_STAA8 Large ribosomal subunit protein bL34 (Gene Name=rpmH)