Structure of PDB 1mec Chain 2 Binding Site BS01

Receptor Information
>1mec Chain 2 (length=256) Species: 12107 (Mengo virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQNTEEMENLSDRVSQDTAGNTVTNTQSTVGRLVGYGTVHDGEHPASCAD
TASEKILAVERYYTFKVNDWTSTQKPFEYIRIPLPHVLSGEDGGVFGATL
RRHYLVKTGWRVQVQCNASQFHAGSLLVFMAPEYPTLDVFAMDNRWSKDN
LPNGTRTQTNRKGPFAMDHQNFWQWTLYPHQFLNLRTNTTVDLEVPYVNI
APTSSWTQHASWTLVIAVVAPLTYSTGASTSLDITASIQPVRPVFNGLRH
EVLSRQ
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1mec Chain 2 Residue 309 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1mec Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S204 S205 H209
Binding residue
(residue number reindexed from 1)		S204 S205 H209
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:1mec, PDBe:1mec, PDBj:1mec
PDBsum1mec
PubMed2155508
UniProtP12296|POLG_ENMGO Genome polyprotein

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