Structure of PDB 1c4y Chain 2 Binding Site BS01

Receptor Information
>1c4y Chain 2 (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQFG
Ligand information
>1c4y Chain 1 (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB1c4y Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E23 G25 M26 P28 W29 D116 H119 P120 C122 L129C Y134 K135 R137 N159 M201 K202 P204 R206 W207
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 D113 H116 P117 C119 L129 Y134 K135 R137 N160 M207 K208 P210 R214 W215
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1c4y, PDBe:1c4y, PDBj:1c4y
PDBsum1c4y
PubMed10713516
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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