Structure of PDB 5hd1 Chain 1b Binding Site BS01

Receptor Information
>5hd1 Chain 1b (length=231) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKELLEAGVHFGHERKRWNPKFARYIYAERNGIHIIDLQKTMEELERTFR
FIEDLAMRGGTILFVGTKKQAQDIVRMEAERAGMPYVNQRWLGGMLTNFK
TISQRVHRLEELEALFASPEIEERPKKEQVRLKHELERLQKYLSGFRLLK
RLPDAIFVVDPTKEAIAVREARKLFIPVIALADTDSDPDLVDYIIPGNDD
AIRSIQLILSRAVDLIIQARGGVVEPSPSYA
Ligand information
>5hd1 Chain 1a (length=1477) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga
caugcaagucgugcgggccgcggguccguggucagcggcggacgggugag
uaacgcgugggugaccuacccggaagagggggacaacccggggaaacucg
ggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuu
gcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaaug
gcccaccaaggcgacgacggguagccggucugagaggauggccggccaca
ggggcacugagacacgggccccacuccucgggaggcagcaguuaggaauc
uuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaag
cccuucgggguguaaacuccugaacccgggacgaaacccccgacgagggg
acugacgguaccgggguaauagcgccggccaacuccgugccagcagccgc
gguaauacggagggcgcgagcguuacccggauucacugggcguaaagggc
guguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugg
gggagcgugggauacgcucaggcuagacggugggagagggugguggaauu
cccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcga
aggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggag
caaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcua
ggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccu
ggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgc
acaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuac
caggccuugacaugcuagggaacccgggugaaagccugggccuagcacag
gugcugcauggccgucgucagcucgugccgugagguguuggguuaagucc
cgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcac
ucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucugg
ucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacua
caaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggccc
aguucggauuggggucugcaacccgaccccaugaagccggaaucgcuagu
aaucgcggaucagccaugccgcggugaauacguucccgggccuuguacac
accgcccgucacgccaugggagcgggcucuacccgaagucgccgggagcc
uacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaag
guagcuguaccggaaggugcggcugga
.....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<
<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<...
....<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>
>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...
>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<......
.>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.
<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>......
..<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<
<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>
..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>
.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<
<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>
....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<
<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<..
..>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..
<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.
<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.
<<.<<<<<<..<<<<<<<<<<......<<........>>..........<
<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<
<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>
>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>..
.>>>>>>>.....<<<<<....>>>>>........>>>>.........>>
>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.
....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>..
....<....<<<<<<<........>>>>>>>....>.....>>>>>>...
.<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<
....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>...
..<<<<<<<<<....>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB5hd1 Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K22 W24 P26 R96 G99 G100 T103 N104 R111 R175 E176 K179
Binding residue
(residue number reindexed from 1)		K16 W18 P20 R90 G93 G94 T97 N98 R105 R169 E170 K173
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hd1, PDBe:5hd1, PDBj:5hd1
PDBsum5hd1
PubMed26809677
UniProtP80371|RS2_THET8 Small ribosomal subunit protein uS2 (Gene Name=rpsB)

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