Structure of PDB 8vtv Chain 1R Binding Site BS01 |
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>8vtv Chain 1A (length=2871)
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agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc gcgcggggggaaccuggggaacugaaacaucucaguacccagaggagagg aaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccua aaccguccggcuuguccgggcggggucguggggcccucggaccgaauccc cagccuagccgaagcuguugggaagcagcgccagagagggugaaagcccc guaggcgaaagguggggggauaggugaggguacccgaguaccccgugguu cguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacu ccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaacc ccgggaggggagugaaauagagccugaaaccgugggcuuacaagcaguca cggccccgagggguuguggcgugccuauugaagcaugagccggcgacuca cggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgag uccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaacc gggcgagcuagcccuggccagggugaagcuggggugagacccaguggagg cccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagu gaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuua gggucagccucaggcgcugacuggggccuguagagcacugauagggcuag ggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggug gagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggga acaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaag gauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccu uuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaug aucggggcuuaagcccagcgccgaagcugcgggucugggggaugacccca ggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcg gcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagaggg ugagaaucccucucgccguaagcccaaggguuccuacgcaauggucguca gcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagg gcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcu cuaggcuagggggaccggagccauggacgagcccggccagaagcgcaggg ugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagc ccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcac aaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaaga gcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggcc ccguaacuucgggagaaggggugcucccuggggugaugagccccggggag ccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugc gaacucguaagaggagguauagggagcgacgcuugcccggugccggaagg ucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggcc guaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccg accugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccg gugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaa agaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccu gcguaggauaggugggagccugugaacccccgccuccgggugggggggag gcgccggugaaauaccacccuggcgcggcugggggccuaacccucggaug gggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaa gguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccgg agagcgcaaggguagaagggggccugacugcgaggccugcaagccgagca ggggcgaaagccgggccuagugaaccgguggucccguguggaagggccau cgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccga gcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcau ccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcg gcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgc cacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccgg aagggacgcaccucugguuucccagcugucccuccaggggcauaagcugg guagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcc cgccccaagaugaggccucccacggcagccgguaaggacccgggaagacc acccgguggaugggccggggguguaagcgccgcgaggcguugagccgacc ggucccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<. .>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...... ...<<....>>...<<<<<.....<<.....>>....>>>>>...<<<.. ..<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<< <.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>> ...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<. ......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>> .>>>>>>.>>...............<<....>>....>>.........<< <<....>>>>..................>>>>>>>>>>>.......<<<< <<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<< <<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..< <<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<< <<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>..... >>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<< .....>>>......>>>>>>......>.>>..<<<<<<....<<<<<... .>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.... <<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>... ..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<.. ....>>>...<<<<.<<<...<<<(((.....<<<<<<...........< <..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>> .........<<......>>...>>>>>....>>>>>>>>>.>>....... ...)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>> >>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>> >>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<< .......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>> .>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>> ...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<< <<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<< <<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<< <..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>.. .>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<.... >>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<< <<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>> >............<<<<<<<<<..<<<.........>>>..<<<<<<<.. ...<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<< <...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<< <<.......>>>>>>........<...........<<<<<<.....>>>> >>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>> >>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..... ....<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<. ..........<<<<<..<<<.......<<<<<<<....>>>>>>>....> >>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....> >>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<..... ......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.. ...<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>> >.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>> >>.............>>>>..>>>>>>.......<<<<.<.<<<<<<... <<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<.. <<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>> >>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>> >>>>>>....<<<<<<<...<<<<..<<<<<<<...............>> >>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>> ...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>> >.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<...... .>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>> >>>.>>>...>>>>....>>> |
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PDB | 8vtv Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. |
Resolution | 2.55 Å |
Binding residue (original residue number in PDB) | M1 R2 H3 L4 K5 S6 R8 K9 N11 R12 H13 S14 H16 R17 R22 N23 Q24 K26 H31 I34 T35 T36 T37 K40 K42 D49 H50 H53 R57 L60 H61 R63 R64 L67 R68 Q71 R77 R90 Q91 G92 G93 R96 K99 R104 R105 G106 D107 |
Binding residue (residue number reindexed from 1) | M1 R2 H3 L4 K5 S6 R8 K9 N11 R12 H13 S14 H16 R17 R22 N23 Q24 K26 H31 I34 T35 T36 T37 K40 K42 D49 H50 H53 R57 L60 H61 R63 R64 L67 R68 Q71 R77 R90 Q91 G92 G93 R96 K99 R104 R105 G106 D107 |
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