Structure of PDB 8vtu Chain 1R Binding Site BS01 |
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>8vtu Chain 1A (length=2871)
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agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc gcgcggggggaaccuggggaacugaaacaucucaguacccagaggagagg aaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccua aaccguccggcuuguccgggcggggucguggggcccucggaccgaauccc cagccuagccgaagcuguugggaagcagcgccagagagggugaaagcccc guaggcgaaagguggggggauaggugaggguacccgaguaccccgugguu cguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacu ccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaacc ccgggaggggagugaaauagagccugaaaccgugggcuuacaagcaguca cggccccgagggguuguggcgugccuauugaagcaugagccggcgacuca cggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgag uccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaacc gggcgagcuagcccuggccagggugaagcuggggugagacccaguggagg cccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagu gaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuua gggucagccucaggcgcugacuggggccuguagagcacugauagggcuag ggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggug gagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggga acaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaag gauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccu uuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaug aucggggcuuaagcccagcgccgaagcugcgggucugggggaugacccca ggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcg gcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagaggg ugagaaucccucucgccguaagcccaaggguuccuacgcaauggucguca gcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagg gcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcu cuaggcuagggggaccggagccauggacgagcccggccagaagcgcaggg ugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagc ccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcac aaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaaga gcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggcc ccguaacuucgggagaaggggugcucccuggggugaugagccccggggag ccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugc gaacucguaagaggagguauagggagcgacgcuugcccggugccggaagg ucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggcc guaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccg accugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccg gugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaa agaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccu gcguaggauaggugggagccugugaacccccgccuccgggugggggggag gcgccggugaaauaccacccuggcgcggcugggggccuaacccucggaug gggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaa gguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccgg agagcgcaaggguagaagggggccugacugcgaggccugcaagccgagca ggggcgaaagccgggccuagugaaccgguggucccguguggaagggccau cgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccga gcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcau ccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcg gcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgc cacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccgg aagggacgcaccucugguuucccagcugucccuccaggggcauaagcugg guagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcc cgccccaagaugaggccucccacggcagccgguaaggacccgggaagacc acccgguggaugggccggggguguaagcgccgcgaggcguugagccgacc ggucccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<. .>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...... ...<<....>>...<<<<<.....<<.....>>....>>>>>...<<<.. ..<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<< <.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>> ...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<. ......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>> .>>>>>>.>>...............<<....>>....>>.........<< <<....>>>>..................>>>>>>>>>>>.......<<<< <<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<< <<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..< <<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<< <<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>..... >>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<< .....>>>......>>>>>>......>.>>..<<<<<<....<<<<<... .>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.... <<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>... ..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<.. ....>>>...<<<<.<<<...<<<(((.....<<<<<<...........< <..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>> .........<<......>>...>>>>>....>>>>>>>>>.>>....... ...)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>> >>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>> >>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<< .......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>> .>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>> ...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<< <<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<< <<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<< <..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>.. .>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<.... >>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<< <<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>> >............<<<<<<<<<..<<<.........>>>..<<<<<<<.. ...<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<< <...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<< <<.......>>>>>>........<...........<<<<<<.....>>>> >>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>> >>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..... ....<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<. ..........<<<<<..<<<.......<<<<<<<....>>>>>>>....> >>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....> >>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<..... ......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.. ...<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>> >.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>> >>.............>>>>..>>>>>>.......<<<<.<.<<<<<<... <<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<.. <<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>> >>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>> >>>>>>....<<<<<<<...<<<<..<<<<<<<...............>> >>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>> ...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>> >.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<...... .>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>> >>>.>>>...>>>>....>>> |
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PDB | 8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. |
Resolution | 2.4 Å |
Binding residue (original residue number in PDB) | M1 R2 H3 L4 K5 S6 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 L20 R22 N23 Q24 K26 S27 H31 I34 T35 T36 T37 P39 K40 K42 R45 D49 H50 H53 R57 L60 H61 R63 R64 R68 Q71 R77 R90 Q91 G92 G93 R96 K99 R104 R105 G106 D107 |
Binding residue (residue number reindexed from 1) | M1 R2 H3 L4 K5 S6 R8 K9 L10 N11 R12 H13 S14 S15 H16 R17 L20 R22 N23 Q24 K26 S27 H31 I34 T35 T36 T37 P39 K40 K42 R45 D49 H50 H53 R57 L60 H61 R63 R64 R68 Q71 R77 R90 Q91 G92 G93 R96 K99 R104 R105 G106 D107 |
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