Structure of PDB 8uew Chain 1I Binding Site BS01

Receptor Information

>8uew Chain 1I (length=176) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TYKFVNMREPSMDMKSVTDRAAQTLLWTELVRGLGMTLSYLFREPATINY
PFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEPRA
DGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYN
KEKLLNNGDKWEAEIAANIQADYLYR

Ligand information

InChI=1S/4Fe.4S

LJBDFODJNLIPKO-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 2.0.7	[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385	S1[Fe]S[Fe]1.S2[Fe]S[Fe]2

Formula

Fe4 S4

Name

IRON/SULFUR CLUSTER

ChEMBL

DrugBank

ZINC

PDB chain

8uew Chain 1I Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8uew High-resolution in situ structures of mammalian respiratory supercomplexes.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	H65 C87 P88 I92 C116 I117 Y118 C119 C122
Binding residue (residue number reindexed from 1)	H65 C87 P88 I92 C116 I117 Y118 C119 C122
Annotation score	1

Gene Ontology

	Molecular Function
GO:0003954	NADH dehydrogenase activity
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045271	respiratory chain complex I

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Cellular Component

External links

PDB	RCSB:8uew, PDBe:8uew, PDBj:8uew
PDBsum	8uew
PubMed	38811722
UniProt	A0A286ZUN9

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