Structure of PDB 5el6 Chain 1I Binding Site BS01

Receptor Information
>5el6 Chain 1I (length=91) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRGPFKH
KDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIE
Ligand information
>5el6 Chain 13 (length=1496) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaa
gacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgc
gugggugaccuacccggaagagggggacaacccggggaaacucgggcuaa
ucccccauguggacccgccccuugggguguguccaaagggcuuugcccgc
uuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccac
caaggcgacgacggguagccggucugagaggauggccggccacaggggca
cugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccg
caaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuu
cgggguguaaacuccugaacccgggacgaaacccccgacgaggggacuga
cgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaa
uacggagggcgcgagcguuacccggauucacugggcguaaagggcgugua
ggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggag
cgugggauacgcucaggcuagacggugggagagggugguggaauucccgg
aguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggca
gccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaac
cggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucu
cugggucuccugggggccgaagcuaacgcguuaagcgcgccgccugggga
guacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaag
cgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggc
cuugacaugcuagggaacccgggugaaagccuggggugccccgcgagggg
agcccuagcacaggugcugcauggccgucgucagcucgugccgugaggug
uuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgg
uucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggagg
ggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcu
acaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgca
aaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagc
cggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguuccc
gggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaa
gucgccgggagccuacgggcaggcgccgaggguagggcccgugacugggg
cgaagucguaacaagguagcuguaccggaaggugcggcuggacacc
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..
<<<.<<<..<<<..<<.<........>.>>>>>......<<.......<<
<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>....
.>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>
>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>
>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.
<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<
....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<..
..>>>>.....>>>>....<<<<<........<<<<.....>>>>.....
.....>>>>>......<<<<<(((...<<<<<.....<<.)))>>.....
..>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...
<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>
>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<
.<..<<<......>>>.....>.>>>>>>>...........<<....>>.
>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<
<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<
<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<..
....<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<
<<<<..<<<<<<<<<<......<<........>>..........<<<<<<
<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>.
..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>.
.<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<
.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>
>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>
.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.
....>>>>>>>...........<<<<<<<........>>>>>>>......
....>>>>>>....<<<<<<<..........>>>>>>>......>>...>
>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...
<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>
>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5el6 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K7 H13 S35 G36 P37 I38 P39 L40 P41 T42 R43 V44 R45 T48 R51 G52 P53 F54 K55 H56 K57 S59 R60 H68 R70
Binding residue
(residue number reindexed from 1)		K1 H7 S29 G30 P31 I32 P33 L34 P35 T36 R37 V38 R39 T42 R45 G46 P47 F48 K49 H50 K51 S53 R54 H62 R64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5el6, PDBe:5el6, PDBj:5el6
PDBsum5el6
PubMed26791911
UniProtQ5SHN7|RS10_THET8 Small ribosomal subunit protein uS10 (Gene Name=rpsJ)

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