Structure of PDB 8uex Chain 1E Binding Site BS01

Receptor Information

>8uex Chain 1E (length=214) Species: 9823 (Sus scrofa)

GALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDL
AQRQNGWLPISAMNKVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVC
TTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPM
VQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLT
EPPKGPGFGVQAGL

Ligand information

• Ligand ID: FES
• InChI: InChI=1S/2Fe.2S
• InChIKey: NIXDOXVAJZFRNF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: [Fe]1S[Fe]S1
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: S1[Fe]S[Fe]1
• Formula: Fe2 S2
• Name: FE2/S2 (INORGANIC) CLUSTER
• PDB chain: 8uex Chain 1E Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8uex High-resolution in situ structures of mammalian respiratory supercomplexes.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): C103 T105 C108 C144 L145 G146 A147 C148 M153
• Binding residue (residue number reindexed from 1): C100 T102 C105 C141 L142 G143 A144 C145 M150
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0046872 metal ion binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0007399 nervous system development
• GO:0048738 cardiac muscle tissue development
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:8uex, PDBe:8uex, PDBj:8uex
• PDBsum: 8uex
• PubMed: 38811722
• UniProt: A0A4X1VRV3