Structure of PDB 6qx9 Chain 1A Binding Site BS01

Receptor Information

>6qx9 Chain 1A (length=98) Species: 9606 (Homo sapiens)

TRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQA
FVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVE

Ligand information

>6qx9 Chain 1 (length=164)

auacuuaccuggcaggggagauaccaugaucacgaaggugguuuucccag
ggcgaggcuuauccauugcacuccggaugugcugaccccugcgauuuccc
caaaugugggaaacucgacugcauaauuugugguagugggggacugcguu
cgcgcuuuccccug

...........<<<<.<<<<<.<<<<<..........>>>>>>>>>>.<<
<<...<<<.<<<<<..........>>>>>.>>>...>>>>.<<<<<<<<<
.......>>>>>>.>>>.>>>>...............<<<<<<..<<<..
..>>>..>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qx9 Mechanism of 5' splice site transfer for human spliceosome activation.
• Resolution: 3.28 Å
• Binding residue (original residue number in PDB): Y13 N15 N16 E19 S48 L49 K50 M51 R52 Q54 F56 K80 Q85 K88 D90 S91 D92
• Binding residue (residue number reindexed from 1): Y8 N10 N11 E14 S43 L44 K45 M46 R47 Q49 F51 K75 Q80 K83 D85 S86 D87

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0030619 U1 snRNA binding
• GO:0042802 identical protein binding
• GO:1990446 U1 snRNP binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0005685 U1 snRNP
• GO:0030532 small nuclear ribonucleoprotein complex
• GO:0046540 U4/U6 x U5 tri-snRNP complex

External links

• PDB: RCSB:6qx9, PDBe:6qx9, PDBj:6qx9
• PDBsum: 6qx9
• PubMed: 30975767
• UniProt: P09012|SNRPA_HUMAN U1 small nuclear ribonucleoprotein A (Gene Name=SNRPA)