Structure of PDB 5el5 Chain 19 Binding Site BS01

Receptor Information
>5el5 Chain 19 (length=273) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVKKFKPYTPSRRFMTVADFSEITKTEPEKSLVKPLKKTGGRNNQGRITV
RFRGGGHKRLYRIIDFKRWDKVGIPAKVAAIEYDPNRSARIALLHYVDGE
KRYIIAPDGLQVGQQVVAGPDAPIQVGNALPLRFIPVGTVVHAVELEPKK
GAKLARAAGTSAQIQGREGDYVILRLPSGELRKVHGECYATVGAVGNADH
KNIVLGKAGRSRWLGRRPHVRGAAMNPVDHPHGGGEGRAPRGRPPASPWG
WQTKGLKTRKRRKPSSRFIIARR
Ligand information
>5el5 Chain 1G (length=1496) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaa
gacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacg
ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga
aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag
ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg
guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg
gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu
aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag
gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga
cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag
cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu
aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca
accgugggggagcgugggauacgcucaggcuagacggugggagagggugg
uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg
auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg
uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug
cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc
gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg
ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga
accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug
gcccuagcacaggugcugcauggccgucgucagcucgugccgugaggugu
uggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcggu
ucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggg
gacgacgucuggucagcauggcccuuacggccugggcgacacacgugcua
caaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaa
aaaggugggcccaguucggauuggggucugcaacccgaccccaugaagcc
ggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccg
ggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaag
ucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggc
gaagucguaacaagguagcuguaccggaaggugcggcuggaucacc
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..
<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>.....
.<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<...
...>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<
<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<
.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>
>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<
......<<<<....>>>>.....>>>>....<<<<<......<.<<<<..
...>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<
<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((
.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<....
.>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<
<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>........
...<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<
<<<...<<...<<<<.........>>>>...>>>>>>>>..........<
<<<<<..<<<<<<<<<.....>>>>>>>>>...<<..))>>.....>>>>
>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<
<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>....
......<<<<<<<...........<<<..<<<<<<<....>>>>>>>...
.>>>.......<<.<<<..<<<<<<.......<<<<<<<<<....>>>..
<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.
....>>>>......>>>>>>.....<<<<<....>>>>>........>>>
>.........>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.
....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>..
...>>>>>>>...........<<<<<<<........>>>>>>>.......
...>>>>>>....<<<<<<<..........>>>>>>>......>>...>>
>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<
.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>
>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
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PDB5el5 Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		Q166 K202
Binding residue
(residue number reindexed from 1)		Q165 K201
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0016740 transferase activity
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5el5, PDBe:5el5, PDBj:5el5
PDBsum5el5
PubMed26791911
UniProtP60405|RL2_THET8 Large ribosomal subunit protein uL2 (Gene Name=rplB)

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