Structure of PDB 8r08 Chain 12 Binding Site BS01

Receptor Information
>8r08 Chain 12 (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAF
DRHCNMVLENVKEMWTEVKPVNKDRYISKMFLRGDSVIVVLRNPL
Ligand information
>8r08 Chain 1 (length=153) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcaggggagauaccaugaucacgaaggugguuuucccagggcgaggcuua
uccauugcacuccggaugugcugaccccugcgauuuccccaaauguggga
aacucgacugcauaauuugugguagugggggacugcguucgcgcuuuccc
cug
<<<<.<<<<<.<<<<<..........>>>>>>>>>>.<<<<...<<<.<<
<<<..........>>>>>.>>>...>>>>.<<<<<<<<<.......>>>>
>>.>>>.>>>>...............<<<<<<..<<<<..>>>>..>>>>
>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution6.1 Å
Binding residue
(original residue number in PDB)		E10 R47 N48 N49 R61 G103 D104
Binding residue
(residue number reindexed from 1)		E1 R38 N39 N40 R52 G84 D85
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0036261 7-methylguanosine cap hypermethylation
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005684 U2-type spliceosomal complex
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0005687 U4 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030532 small nuclear ribonucleoprotein complex
GO:0034709 methylosome
GO:0034715 pICln-Sm protein complex
GO:0034719 SMN-Sm protein complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070062 extracellular exosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtP62316|SMD2_HUMAN Small nuclear ribonucleoprotein Sm D2 (Gene Name=SNRPD2)

[Back to BioLiP]