Structure of PDB 8fnk Chain 10 Binding Site BS01

Receptor Information

>8fnk Chain 10 (length=416) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PLPVSYSPGSVTSTAITAHCDVLSECVAKADELAVQLKTQEGMEEFVEEL
KTSATNEMTALVKQMQTTPLLQRAGMHELRRTLYYTTSLKERDWLEEKQY
TAAMRMLTVEVLRRDGDGVLSADDVLYVTTHVVTANFYNRHLWNRMEKSL
LKFSNYENIDMSSVKAFSTRLFKTRRGCAKETLDIRRKVLLAMSRRVGVL
ANDFDLPSLLGVLQCYTVHDLTPFHLEPLAIRATNHVGDFTPHECATLAH
VLRKWRTMRLEVCERLVERICTSDQLTHHMANAAMIAIRTCFNQVSDGGR
NAMNAEPTRQKLRAMGEQIGCRLDEVEYPALPVILSILDVVVTLKIYVPK
KCLQVIFSQANDMVAIVMEQKDDPITAEEGRQLQALLSHYGNDLAPELSQ
RMKEAFREGVLPDEAS

Ligand information

>8fnk Chain m (length=51) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	8fnk Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
Resolution	3.7 Å
Binding residue (original residue number in PDB)	L266 F268 L306 S309 R310
Binding residue (residue number reindexed from 1)	L151 F153 L191 S194 R195

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

	Biological Process
GO:0000963	mitochondrial RNA processing
GO:0016554	cytidine to uridine editing
GO:0048255	mRNA stabilization

	Cellular Component
GO:0005739	mitochondrion
GO:0031019	mitochondrial mRNA editing complex

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Cellular Component

External links

PDB	RCSB:8fnk, PDBe:8fnk, PDBj:8fnk
PDBsum	8fnk
PubMed	37410820
UniProt	Q57VS6

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