Structure of PDB 8i0w Chain 1 Binding Site BS01

Receptor Information
>8i0w Chain 1 (length=393) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRS
LQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYI
VDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVF
KPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQ
AHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDFNKPLFSASGLPTMFPM
TDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVR
CLWHPKLNQIMVGTGNGLAKVYYDPDRLDPLKSHKPEPPVAGPGRGGRVG
THGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVS
Ligand information
>8i0w Chain H (length=139) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuua
auauguccucuaccgaggacaauauuaaggauuuuuggagcagggagcca
cgcaucgaccugguauugcaguaccuccaggaacggugc
...............................................<<<
<<<<<<<<<<....>>>>>>.>>>>>>>...............<......
><<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8i0w Molecular basis for the activation of human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		F221 R258 D554 R555
Binding residue
(residue number reindexed from 1)		F48 R85 D326 R327
Gene Ontology
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0035861 site of double-strand break

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Molecular Function
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Cellular Component
External links
PDB RCSB:8i0w, PDBe:8i0w, PDBj:8i0w
PDBsum8i0w
PubMed39068178
UniProtQ9NW82|WDR70_HUMAN WD repeat-containing protein 70 (Gene Name=WDR70)

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