Structure of PDB 8fok Chain 1 Binding Site BS01

Receptor Information
>8fok Chain 1 (length=1046) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREGK
TPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLLP
YQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIKG
ADFSHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPKENKQEIV
SITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAALAKQKLP
GRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAHRMHDLNI
PTFSSIGRRLRRTWPEKFGNMNHFFISDICSGRLICDIANEMGQSLTPKC
QSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMALQENITNCMIS
AEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYILLHEFSRNGFI
VPDKKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNK
EDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKKRVQCDIRQQAL
KLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESMNLLVV
YGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLEIDIDNVFKKLLL
HAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRREFCPLSRDVSIHVLNTI
LSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKLSKDPKAYPGG
KNMPAVQVALRMRKAGRVVKAGSVITFVITKSVAERAHALNEVMIKSNNL
IPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALGLDSKKYFRREGGNN
NGEDINNLQPLETTITDVERFKDTVTLELSCPSCDKRFPFGGIVSSNYYR
VSYNGLQCKHCEQLFTPLQLTSQIEHSIRAHISLYYAGWLQCDDSTCGIV
TRQVSVFGKRCLNDGCTGVMRYKYSDKQLYNQLLYFDSLFDCEKNKKQEL
KPIYLPDDLDYPKEQLTESSIKALTEQNRELMETGRSVVQKYLNDC
Ligand information
Receptor-Ligand Complex Structure
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PDB8fok Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Resolution3.56 Å
Binding residue
(original residue number in PDB)		H684 F685 F686 E702 T792 R793 A794 K842 Y843 G845 Y951 G955 Y956 K1046 K1047 N1145 R1224 G1258
Binding residue
(residue number reindexed from 1)		H323 F324 F325 E341 T431 R432 A433 K455 Y456 G458 Y558 G562 Y563 K653 K654 N752 R818 G852
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000510 H3-H4 histone complex chaperone activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006272 leading strand elongation
GO:0006273 lagging strand elongation
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006279 premeiotic DNA replication
GO:0006302 double-strand break repair
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005658 alpha DNA polymerase:primase complex
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fok, PDBe:8fok, PDBj:8fok
PDBsum8fok
PubMed37344454
UniProtP13382|DPOLA_YEAST DNA polymerase alpha catalytic subunit A (Gene Name=POL1)

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