Structure of PDB 7tql Chain 1 Binding Site BS01

Receptor Information
>7tql Chain 1 (length=619) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EERAYDKAKRRIEKRRLEHSKNVTEKDKLRAPIICVLGHVDTGKTKILDK
LRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLI
IDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCP
FIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQ
QGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRL
AHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
IRGLLTPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVA
YKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKT
SEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMAD
SLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQY
IFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDV
AKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
EMQKSDWQLIVELKKVFEI
Ligand information
>7tql Chain 2 (length=1656) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucuagcguuuacuuugaaaaaauuagaguguucaaagca
ggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucua
uuuuguugguuuucggaacugaggccaugauuaagagggacggccggggg
cauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgg
accagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaa
gucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacg
augccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcu
uccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcu
gaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcgg
cuuaauuugacucaacacgggaaaccucacccggcccggacacggacagg
auugacagauugauagcucuuucucgauuccgugggugguggugcauggc
cguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacga
gacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuaga
gggacaaguggcguucagccacccgagauugagcaauaacaggucuguga
ugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcg
uguccuacgccggcaggcgcggguaacccguugaaccccauucgugaugg
ggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagug
cgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcc
cgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccg
ccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucua
gaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaagga
ucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<....<<.<<<....>>>..>>.....>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<..>...<<<<<<.<.......<<...<.......>..
<<<.>>>....>>......>.>>>..>>>........<.<<.<<<<<<<.
..............>>>>>>>.>>.>....>>....<<<<<<..<...<<
<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.
......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....
<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>........
..<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>
...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<.
<......<<........>>..........<<<<<......<<<<<<....
...<<.<<<........>>>.>>.....>>>>>>...<..<<<..<<.<<
<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>..
..<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>.
.>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>
>>>>.>.......>>>>>...>..>>>>.>>>.....<<.<<<.......
.<.<<<.<<<<....>>>>.>>>....>.........>>>.>>.......
.....<<<<<..........>>>>>...........>>>>>.....<<<<
<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..
<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<
<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>.
..>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>...
......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tql eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G868 M869 G870 R902 K916 K936 H1014 K1015 K1016 R1040
Binding residue
(residue number reindexed from 1)		G268 M269 G270 R302 K316 K336 H414 K415 K416 R440
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7tql, PDBe:7tql, PDBj:7tql
PDBsum7tql
PubMed35732735
UniProtO60841|IF2P_HUMAN Eukaryotic translation initiation factor 5B (Gene Name=EIF5B)

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