Structure of PDB 7ood Chain 1 Binding Site BS01

Receptor Information

>7ood Chain 1 (length=59) Species: 272634 (Mycoplasmoides pneumoniae M129)

MKVKSAAKKRFKLTKSGQIKRKHAYTSHLAPHKTTKQKRHLRKQGTVSAS
DFKRIGNLI

Ligand information

>7ood Chain 3 (length=2879)

aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaagg
acguguuaaccugcgauaagcuucggguaggugguaagaaccucagaucc
ggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaau
ugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucuc
aguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagc
gaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugc
aauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaa
agggugauagccccguauuugaaauuguuuucauaccuagcgagaucccu
gaguagcucggaaaacguuauuuugagugaaucugcccagaccauugggu
aagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaa
aggugaaaagaacccagagaugggagugaaauagauucugaaaccauaug
ccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaagu
augagccggcgaguuaugauagcaagcguuaguuaaccaggagaugggga
gcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacc
cgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaa
cuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugau
uaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaau
agcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacuga
auguaugauggcgccaccuaggcguacugaauacaauuaaacucugaaug
ccauuuauuuuauucucgcagucagacagugggggauaagcuucauuguc
aagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaag
uggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagc
agccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcg
ccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuu
auaucuugugguagacgagcguuguauuggaguugaagucaaagcgugag
cauugguggauccaauacaagugagaaugccggcaugaguaacgcuuggg
agugagaaucucccaaaccgauugacuaagguuuccuggaccagggucgu
ccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgau
ggacaacagguuaauauuccuguacuuacaguuagacugauggagugaca
aagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggug
guacaauaggcaaauccguugugcauaacauugagugaugaugucgagug
aaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuagggu
uaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagag
gauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaac
cccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaa
gaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaa
ggugauguauauggggugacaccugcccagugcuggaagguuaaagaagg
agguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccg
uaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgu
cccgcuugaaugguguaaccaucucuugacugucucggcuauagacucgg
ugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaa
gaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucaug
uagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaug
cgaaagguggaauacuacccuugguugugugcuguucuaauugguaacug
uuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguugga
aaucguauguagaguguaaugguguaagggugcuugacugugagacauac
aggucgaacaggugagaaaucaggucauagugauccggugguccaguaug
gaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcuga
uacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucga
cucaucucauccucgagcugaagcagguucgaaggguucggcuguucgcc
gauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggu
cccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacg
agaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcug
caccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaag
ugugaaacuaucucaaagauuaaucuucccauuucgaaaguaagagccgu
caaagacgaugacguugauagguuacagguguaagcauagugauauguug
agcugaguaauacuaauugcucgaggacu

<<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<
<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>
>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<
<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>..
....>>>>>.>.........<<....>>..<<<<<<.....<<.....>>
....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<
.....<....<<<<<<<<<<.<<<...<<<<<......>>>>>((.....
.<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>
.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>
..)))......]].>>>>>>>.]]...............<<....>>...
.]].........<<<<....>>>>.............}....>>>>>>.>
>>>.......<<<<..<<<<......>>>>..>>>>...<<<........
>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...
>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<
.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>
>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>
>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<
<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<.
.<<<<<...<.<<<<.....>>>>..>...>>>>>..>>..>>.......
>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>
....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<....
.......<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......
>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.
>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<..
..>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>
>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<
<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....
>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...
>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<<...<
<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<
<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.
......>>...>>>>>....>>>....>>>>........>>>>>..>>..
...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<...
..>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<
<<<.....<..>......>>>>><<<<<<......>>>>>>.........
...<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....
>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<
<<<<..<<....>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<
<.......>>>>>>........<...........<.<<<.......>>>.
>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>
>...........<<<<<........>>>>>..<<<<<<<..(((.[[...
...<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<..
.........<<<<<..<<<......<<<<<<<......>>>>>>>...>>
>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<
.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>
>..))>>>>>>>.............>>>>..]]>>>>.......<<<<..
.<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<.......
........>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>
>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>
>>>....>>>.>>>........>>>>>>>...<<..>>.....<<<<<<<
<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>..
.>>>..>>>>>.>>>...>>>>....>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ood Visualizing translation dynamics at atomic detail inside a bacterial cell.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): K2 V3 K4 S5 A6 K8 K9 R10 K15 K20 R21 A24 Y25 S27 H28 L29 A30 P31 H32 K36 Q37 K38 R39 H40 R42 K43 Q44 S48 S50 D51 R54
• Binding residue (residue number reindexed from 1): K2 V3 K4 S5 A6 K8 K9 R10 K15 K20 R21 A24 Y25 S27 H28 L29 A30 P31 H32 K36 Q37 K38 R39 H40 R42 K43 Q44 S48 S50 D51 R54

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ood, PDBe:7ood, PDBj:7ood
• PDBsum: 7ood
• PubMed: 36171285
• UniProt: P75447|RL35_MYCPN Large ribosomal subunit protein bL35 (Gene Name=rpmI)