Structure of PDB 7of0 Chain 1 Binding Site BS01

Receptor Information

>7of0 Chain 1 (length=52) Species: 9606 (Homo sapiens)

KNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVVKQRVLFVEKKKIR
SL

Ligand information

>7of0 Chain A (length=1376)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacccaaauaaaguauaggcgauagaaauugaaauggcgcaauag
auauaguaccgcaagggaaagacaagcauaauauagcaaggacuaacccc
uauaccuucugcaaugaauuaacuagaaauaacuuugcaaggagagccaa
agcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagc
acacccgucuauguagcaaaauagugggaagauuuauagguagaggcgac
aaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguu
caacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacugu
uaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagag
agaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauua
agaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacucc
ucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuagu
auaaguaacaugaaaacauucuccuccgcauaagccugcgucagauacug
acaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccu
cacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagua
aaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccuc
uagcaucaccaguauuagaggcaccgccuuccuuaaauagggauggcucc
acgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccg
ugagaggcgggcauaacacagcaagacgagagacccuauggagcuuuaau
uuauuaaugcaaacaaccugcauuaaaaauuucgguuggggcgaccucgg
agcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaag
cgaaccuuugauccaauaacuugaccaacggaacaaguuacccuagggaa
auccuauucuagaguccauaucaacaauaggguuuacgaccucguuggau
caggacaucccgauggugcagccgcuauuaaagguucguuuguucaacga
uuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuu
cuaucuacuuuaauuccucccuguacgaaaggacaagagaaauaaggccu
acuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauu
auacccacacacccaagaacaggguu

<<<.......<<<<.................................<..
....>...............<<.....>>...........>>.>>.....
........<<....>>........>>>...........<<<.......>>
>...<.<<....>>.>.<<<<<<.........<<<.<<..<<....>>..
.>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>
...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<....
...>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>
><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>
>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<
.<<<...<..............<....<<<.........>>>....>...
....<<<......>>>..........................>...>>>>
>>........>>>>>>...<<<<<......>>>>>.........>>>>>>
.......<<..<<<....>>><<<<..<<<<........<<<<<...>>>
>>......<<<...<<<<.......................>>>>.....
..>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<
<.<<.........<......<<<<<<..<<<.........>>>...<<<<
<<.............>>>>>>....<<<.<<<<.....>>>>..>>>...
.>>.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<
.......>>>>>.......<<..<<<.<<<...<<<<<.<<<<<<..<<<
<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<((((.>>>><<<<
<<...........>>>>>>...<.....<<<..<<<<.....>>>>..>>
>....>.......<<<....>>>............>>>>..>>>>>>>.<
<<<<<<<<...<<.......>>...>>>>>>>>>.....)))).<<<<<.
.<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>
.....>>>>>......>>>>>.....<<<<<<<....>>>.>>>>...>>
>..>>>.>>...<<<.<<<.................>>>.>>><<<<<..
.<<<....>>>.>>>>>......<<<.<............>.>>>.....
..........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of0 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): N15 R19 F30 N31 L43 L44 H45 Y46 K51 R53 I62 R63
• Binding residue (residue number reindexed from 1): N2 R6 F17 N18 L30 L31 H32 Y33 K38 R40 I49 R50

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of0, PDBe:7of0, PDBj:7of0
• PDBsum: 7of0
• PubMed: 34135319
• UniProt: O75394|RM33_HUMAN Large ribosomal subunit protein bL33m (Gene Name=MRPL33)