Structure of PDB 6h8k Chain 1 Binding Site BS01

Receptor Information

>6h8k Chain 1 (length=325) Species: 4952 (Yarrowia lipolytica)

MIINIVEILIFLVCVLFSVAYLTVAERKTLAYMQRRLGPNFVGYYGLLQA
FADAVKLLLKEIVLPESNYIILVISPLITLITALIGWVVIPLGPGITLGE
LNLGILFSLAIGSLGVFGSLLSGWSSNSKYSLLGSIRSTAQLISYELILT
SIFIIIIMFVSSLNITTIIETQRVVWYCIPLLPLLLIFFIASVAETARPP
FDLTESESELVSPFVFFFLAEYSNIILISAFNGYLLLGGYLSFNYSYLFN
ILFNDYSYVSFLFEGLINSSAYAIKLVFLMFSFIWVRAAFPRFTYDNLIN
FCWIILLPLLFGIFLIIPSTLYIFD

Ligand information

>6h8k Chain P (length=28) Species: 4952 (Yarrowia lipolytica)

AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6h8k Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.
• Resolution: 3.79 Å
• Binding residue (original residue number in PDB): C14 S18 Y21 K28 I97 S279 A283
• Binding residue (residue number reindexed from 1): C14 S18 Y21 K28 I96 S269 A273

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0008137 NADH dehydrogenase (ubiquinone) activity

Biological Process

• GO:0009060 aerobic respiration
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:6h8k, PDBe:6h8k, PDBj:6h8k
• PDBsum: 6h8k
• PubMed: 30374105
• UniProt: Q9B6E8|NU1M_YARLI NADH-ubiquinone oxidoreductase chain 1 (Gene Name=ND1)