Structure of PDB 5z56 Chain 1 Binding Site BS01

Receptor Information
>5z56 Chain 1 (length=1038) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGYHAPVADPFAEHRPPKIADREDEYKKHRRTMIISAEKAKAGELKVVNG
AAASDQTPGATPKKLSSWDQAETPGHTPSLRWDETPGRAKGSETPGATPG
SKIWDPTPSAETPRTDRGGDSIGETPTPGASKRKERNRPLSDEELDAMFP
EGYKVLPPPAGYVPIRTPARKLTATPTPLGGMTGFHMQTEMKSVNDQPSG
NLPFLKPDDIQYFDKLLVDVDESEEQKERKIMKLLLKIKNGTPPMRKAAL
RQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDL
VRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPD
IDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARHTGIK
IVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAALAEAA
TPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYT
REVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFFK
HFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRK
MVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGT
VVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVMKTCQ
EEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPPIKDL
LPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELL
KAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAI
AIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYI
YAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLLNYVW
PNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVRDVYW
KIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
Ligand information
>5z56 Chain G (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccuccgaacgguaagagccuagcauguagaacugguuaccuaugaugu
cauacuuauccugucccuuuuuuuucc
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5z56 Structure of the human activated spliceosome in three conformational states.
Resolution5.1 Å
Binding residue
(original residue number in PDB)		A514 A515 Q518 E622 R630 Q699 K700 E714 P780 R831 K1070 K1071 R1075 E1105 Q1107 H1225
Binding residue
(residue number reindexed from 1)		A248 A249 Q252 E356 R364 Q433 K434 E448 P514 R565 K804 K805 R809 E839 Q841 H959
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5z56, PDBe:5z56, PDBj:5z56
PDBsum5z56
PubMed29360106
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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