Structure of PDB 3jc2 Chain 1 Binding Site BS01

Receptor Information

>3jc2 Chain 1 (length=401) Species: 9615 (Canis lupus familiaris)

PFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIGTLMELG
ISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIV
YVMTGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETI
VWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPN
LMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPI
ILQSALVSNLYVISQMLSARFPVGGLCHYLSPPESFGSVLEDPVHAVVYI
VFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNR
YIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQ
S

Ligand information

>3jc2 Chain w (length=19) Species: 9913 (Bos taurus)

RLLLLLVVSNLLLCQGVVS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3jc2 Structure of the Sec61 channel opened by a signal sequence.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): I90 Q127 L297 N300 L301 F375
• Binding residue (residue number reindexed from 1): I60 Q97 L256 N259 L260 F310

Gene Ontology

Molecular Function

• GO:0005048 signal sequence binding
• GO:0005515 protein binding
• GO:0008320 protein transmembrane transporter activity
• GO:0043022 ribosome binding

Biological Process

• GO:0006613 cotranslational protein targeting to membrane
• GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
• GO:0015031 protein transport
• GO:0031204 post-translational protein targeting to membrane, translocation
• GO:0039019 pronephric nephron development
• GO:0045047 protein targeting to ER
• GO:0045048 protein insertion into ER membrane

Cellular Component

• GO:0005783 endoplasmic reticulum
• GO:0005784 Sec61 translocon complex
• GO:0005789 endoplasmic reticulum membrane
• GO:0016020 membrane

External links

• PDB: RCSB:3jc2, PDBe:3jc2, PDBj:3jc2
• PDBsum: 3jc2
• PubMed: 26721998
• UniProt: P38377|S61A1_CANLF Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)