Structure of PDB 2hwd Chain 1 Binding Site BS01

Receptor Information
>2hwd Chain 1 (length=283) Species: 12134 (Human rhinovirus 1A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYIDEVLNEVLVVPNIKESHHTTSNSAPLLDAAETGHTSNVQPEDAIETR
YVITSQTRDEMSIESFLGRSGCVHISRIKVDYTDYNGQDINFTKWKITLQ
EMAQIRRKFELFTYVRFDSEITLVPCIAGRGDDIGHIVMQYMYVPPGAPI
PSKRNDFSWQSGTNMSIFWQHGQPFPRFSIPFLSIASAYYMFYDGYDGDN
TSSKYGSVVTNDMGTICSRIVTEKQKLSVVITTHIYHKAKHTKAWCPRPP
RAVPYTHSHVTNYMPETGDVTTAIVRRNTITTA
Ligand information
>2hwd Chain 4 (length=19) Species: 12134 (Human rhinovirus 1A) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YFNINYFKDAASSGASRLD
Receptor-Ligand Complex Structure
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PDB2hwd A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		N5 E9 V14 L15 D63 E68 D122 P185 K244 H245
Binding residue
(residue number reindexed from 1)		N1 E5 V10 L11 D59 E64 D118 P181 K240 H241
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:2hwd, PDBe:2hwd, PDBj:2hwd
PDBsum2hwd
PubMed8383771
UniProtP23008|POLG_HRV1A Genome polyprotein

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