Structure of PDB 8cst Chain 0 Binding Site BS01

Receptor Information
>8cst Chain 0 (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRPRLIAELARRVRALREQLNRPRDSQLYAVDYETLTRPFSGRRLPVRAW
ADVRRESRLLQLLGRLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYT
AQNLDHGKAWGILTFKGKTESEAREIEHVMYHDWRLVPKHEEEAFTAFTP
APEDSLASVPYPPLLRAMIIAERQKNGDTSTEEPMLNVQRIRMEPWDYPA
KQEDKGRAKGT
Ligand information
>8cst Chain A (length=888) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
ggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucaaauaaagcuaaaacucaccugaguuguaaaaaacuccaguuga
cacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagc
uaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccuc
aacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuu
aaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguu
cuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuaua
uaccgccaucuaacccugaugaaggcuacaaaguacguuaggucaaggug
uagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacu
acgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaac
ugagaguagagugcuuaguugaacagggcccugaagcgcgucacccuccu
caaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauag
aggagacaaguaaguguacuggaaagugcacuuggacg
..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<
..<......>......<<.......<<<<.<..<<<.....>>>.>..>>
>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..
<<<<.....<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>
.............<<....>>.>>>>>>.....>>>>...>>>>....<<
<<<<...<<...<<<<.........>>>>...>>>>>>>>..........
<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>
.....>>..>>>>>>......<<<<<<<...<<<.<<<<<..<<<<<<<<
.......<<........>>..........<<<<<<<.......<<.<<<.
.<<.<<<<.<..<<<<<.....>>>.......>>..>.>.>>>....>>>
>>>>....>>>>>>>.....>>>>>>>>.....<<<<.....>>>>....
.<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<
<<<<.........>>>>>>>.....>>>...>>>>>>>.......<<<<<
<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>
>>>>>......<<<<<<<<<....>>>>>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8cst Principles of mitoribosomal small subunit assembly in eukaryotes.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		R7 P8 R9 L10 I11 A15 V18 R19 R22 L25 R29 Y34 R43 R48 L50 P51 R53 A54 D57 L73 R99 V100 R101 Y104 M135 Y136 H137 W201 K210 G211 R212 A213
Binding residue
(residue number reindexed from 1)		R2 P3 R4 L5 I6 A10 V13 R14 R17 L20 R24 Y29 R38 R43 L45 P46 R48 A49 D52 L68 R94 V95 R96 Y99 M130 Y131 H132 W196 K205 G206 R207 A208
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cst, PDBe:8cst, PDBj:8cst
PDBsum8cst
PubMed36482135
UniProtP82930|RT34_HUMAN Small ribosomal subunit protein mS34 (Gene Name=MRPS34)

[Back to BioLiP]