Structure of PDB 7a5j Chain 0 Binding Site BS01

Receptor Information
>7a5j Chain 0 (length=108) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAPKNRRTIEVNRCRRRNPQKLIKVKNNIDVCPECGHLKQKHVLCAYCYE
KVCKETAEIRRQIGKQEGGPFKAPTIETVVLYTGETPSEQDQGKRIIERD
RKRPSWFT
Ligand information
>7a5j Chain A (length=1492) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagca
cacccgucuauguagcaaaauagugggaagauuuauagguagaggcgaca
aaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguuc
aacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguua
guccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagag
aguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaag
aaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccuc
acacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguau
aaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugac
aauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccuca
cugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaa
aggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucua
gcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacgg
ccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaau
agggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuua
accagugaaauugaccugcccgugaagaggcgggcauaacacagcaagac
gagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaa
acccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuauucuagaguccauaucaacaauag
gguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcua
uuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucag
accggaguaauccaggucgguuucuaucuacuuuauuccucccuguacga
aaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaau
gauaucaucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>...........<<.....>>.......>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>.
..<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.....
..>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>>
<<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.
<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<
<<...<..............<....<<<.........>>>....>.....
..<<<......>>>..........................>...>>>>>>
........>>>>>>...<<<<<......>>>>>.........>>>>>>..
.....<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>
......<<<...<<<<.......................>>>>.......
>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.
<<.........<......<<<<<<..<<<.........>>>...<<<<<<
.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>
>...<<........>>...........<...........<<<<<<.....
>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>
>>>.>>...........<<<<<........>>>>>.......<<..<<<.
<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............
<<<....>>>................>>>>>>>>>>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>...........<....>..............>>>>
..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>
>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>
>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<
<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.........
........>>>.>>><<<<<...<<<....>>>.>>>>>......<<<..
..............>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a5j Elongational stalling activates mitoribosome-associated quality control.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		A79 A80 P81 K82 N83 R84 R85 T86 I87 V89 N90 R91 C92 R93 R94 R95 N96 Q98 K99 N106 H120 R138 R139 G142 P148 F149
Binding residue
(residue number reindexed from 1)		A1 A2 P3 K4 N5 R6 R7 T8 I9 V11 N12 R13 C14 R15 R16 R17 N18 Q20 K21 N28 H42 R60 R61 G64 P70 F71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a5j, PDBe:7a5j, PDBj:7a5j
PDBsum7a5j
PubMed33243891
UniProtQ9BYC8|RM32_HUMAN Large ribosomal subunit protein bL32m (Gene Name=MRPL32)

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