Structure of PDB 6hkt Chain 0 Binding Site BS01

Receptor Information
>6hkt Chain 0 (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQA
VLLPK
Ligand information
>6hkt Chain I (length=1122) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaccctatacgcggccgccctggagaatcccggtgccgaggccgctca
attggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcc
cccgcgttttaaccgccaaggggattactccctagtctccaggcacgtgt
cagatatatacatcctgtgcatgtattgaacagccccgagaccctatacg
cggccgccctggagaatcccggtgccgaggccgctcaattggtcgtagac
agctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaac
cgccaaggggattactccctagtctccaggcacgtgtcagatatatacat
cctgtgcatgtattgaacagccccgagaccctatacgcggccgccctgga
gaatcccggtgccgaggccgctcaattggtcgtagacagctctagcaccg
cttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggggatt
actccctagtctccaggcacgtgtcagatatatacatcctgtgcatgtat
tgaacagccccgagaccctatacgcggccgccctggagaatcccggtgcc
gaggccgctcaattggtcgtagacagctctagcaccgcttaaacgcacgt
acgcgctgtcccccgcgttttaaccgccaaggggattactccctagtctc
caggcacgtgtcagatatatacatcctgtgcatgtattgaacagccccga
gaccctatacgcggccgccctggagaatcccggtgccgaggccgctcaat
tggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccc
cgcgttttaaccgccaaggggattactccctagtctccaggcacgtgtca
gatatatacatcctgtgcatgtattgaacagccccgagaccctatacgcg
gccgccctggagaatcccggtgccgaggccgctcaattggtcgtagacag
ctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccg
ccaaggggattactccctagtctccaggcacgtgtcagatatatacatcc
tgtgcatgtattgaacagcgat
Receptor-Ligand Complex Structure
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PDB6hkt Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.
Resolution9.7 Å
Binding residue
(original residue number in PDB)		R29 R42 K75 T76 R77
Binding residue
(residue number reindexed from 1)		R16 R29 K62 T63 R64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hkt, PDBe:6hkt, PDBj:6hkt
PDBsum6hkt
PubMed30392928
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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